Loratadine CAS#79794-75-5
Loratadine is a widely used non-hormonal antiallergic medication, classified as a second-generation long-acting tricyclic antihistamine. It acts quickly with potent effects, metabolizing into the more active desloratadine after human absorption. By competitively blocking histamine H1 receptors, it alleviates histamine-induced allergic reactions, with no significant anticholinergic or central depressant effects. Clinically, it relieves allergic rhinitis symptoms (e.g., sneezing, runny nose, nasal and ocular itching/burning) and addresses allergic skin conditions like chronic urticaria. Toxicologically, animal studies show no mutagenic or teratogenic properties.
Loratadine Chemical Parameters
Melting point | 134-136°C |
Boiling point | 531.3±50.0 °C(Predicted) |
density | 1.261±0.06 g/cm3(Predicted) |
RTECS | TM6129200 |
storage temp. | 2-8°C |
solubility | DMSO: 26 mg/mL, soluble |
form | powder |
pka | 4.27±0.20(Predicted) |
color | white |
Water Solubility | It is soluble in DMSO (50 mg/ml), ethanol (77 mg/ml at 25°C), water (<1 mg/ml at 25°C), chloroform, and methanol. |
Merck | 145578 |
BCS Class | 2 |
Stability: | Stable, but may be heat sensitive - refrigerate. Incompatible with strong oxidizing agents. |
InChIKey | JCCNYMKQOSZNPW-UHFFFAOYSA-N |
CAS DataBase Reference | 79794-75-5(CAS DataBase Reference) |
EPA Substance Registry System | 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-, ethyl ester (79794-75-5) |
Safety Information | |
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 22-24/25-36-26 |
RIDADR | 3077 |
WGK Germany | 2 |
HS Code | 29333990 |
Hazardous Substances Data | 79794-75-5(Hazardous Substances Data) |
Loratadine CAS#79794-75-5
These antihistamines exhibit high selectivity for peripheral H1 receptors, delivering potent, long-lasting effects. They are indicated for allergic arthritis, allergic rhinitis, and chronic urticaria, while also relieving both nasal and non-nasal symptoms of seasonal allergic rhinitis as a national Class II new antiallergic drug.
Factory Show
As an ISO-certified chemical exporter with 15 years of professional experience, we leverage leading production technology, advanced equipment, and a professional team to provide high-quality chemical raw materials to over 2,000 companies worldwide. Our products are widely used in pharmaceuticals, agriculture, food manufacturing, and industrial production, with business spanning six continents. We are committed to providing reliable supply chain support and solutions to customers across various industries.
