N,N-Dimethylformamide CAS#68-12-2
CAS Number: 68-12-2
Chemical Formula: C3H7NO
Synonyms:
Amide,n,n-dimethyl-formicaci
Dimethylamid kyseliny mravenci
N,N-DIMETHYLFORMAMIDE, 4X25 ML
Appearance: Colorless Liquid
HS Code: 29241990
MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)
Products Description of N,N-Dimethylformamide CAS#68-12-2
Dimethylformamide (DMF) is a colorless, flammable liquid with a fishy smell. It has a molecular weight of 73.11, a boiling point of 153°C, a freezing point of -61°C, a flash point of 58°C, and a vapor pressure of 3 mmHg at 20°C.
This substance is soluble in both water and organic solvents, and it poses multiple hazards. These include flammability (with explosive limits ranging from 2.2% LEL to 15.2% UEL), toxicity, carcinogenicity, mutagenicity, and skin-irritating properties.
DMF is widely utilized across various industries as a solvent, playing a key role in the production of acrylic fibers, pharmaceuticals, dyes, petroleum products, and organic chemicals. It also functions as a gasoline additive and finds applications in the electronics field.
Parameters
Melting point | -61 °C (lit.) |
alpha | 0.94 º |
Boiling point | 153 °C (lit.) |
density | 0.944 g/mL (lit.) |
vapor density | 2.5 (vs air) |
vapor pressure | 2.7 mm Hg ( 20 °C) |
refractive index | n20/D 1.430(lit.) |
Fp | 136 °F |
storage temp. | Store at +5°C to +30°C. |
solubility | water: miscible |
pka | -0.44±0.70(Predicted) |
form | liquid |
color | APHA: ≤15 |
PH | 7 (200g/l, H2O, 20℃) |
Odor | Faint, ammonia-like odor detectable at 100 ppm |
Relative polarity | 0.386 |
Odor Threshold | 1.8ppm |
explosive limit | 2.2-16%(V) |
Water Solubility | soluble |
λmax | λ: 270 nm Amax: 1.00 |
Sensitive | Hygroscopic |
Merck | 14,3243 |
BRN | 605365 |
Exposure limits | NIOSH REL: TWA 10 ppm (30 mg/m3), IDLH 500 ppm; OSHA PEL: TWA 10 ppm; ACGIH TLV: TWA 10 ppm (adopted). |
Dielectric constant | 36.710000000000001 |
InChIKey | ZMXDDKWLCZADIW-UHFFFAOYSA-N |
LogP | -1.010 |
Surface tension | 35.20mN/m at 298.15K |
Surface tension | 37.1mN/m at 20°C |
CAS DataBase Reference | 68-12-2(CAS DataBase Reference) |
NIST Chemistry Reference | Formamide, N,N-dimethyl-(68-12-2) |
IARC | 2A (Vol. 47, 71, 115) 2018 |
EPA Substance Registry System | N,N-Dimethylformamide (68-12-2) |
Safety Information
Hazard Codes | T |
Risk Statements | 61-20/21-36 |
Safety Statements | 53-45 |
RIDADR | UN 2265 3/PG 3 |
OEB | A |
OEL | TWA: 10 ppm (30 mg/m3) [skin] |
WGK Germany | 1 |
RTECS | LQ2100000 |
F | 3-10 |
Autoignition Temperature | 445 °C |
Hazard Note | Toxic |
TSCA | Yes |
HazardClass | 3 |
PackingGroup | III |
HS Code | 29241990 |
Hazardous Substances Data | 68-12-2(Hazardous Substances Data) |
Toxicity | LD50 in mice, rats (ml/kg): 6.8, 7.6 orally; 6.2, 4.7 i.p. (Bartsch) |
IDLA | 500 ppm |
Product Application of N,N-Dimethylformamide CAS#68-12-2
N,N-dimethylformamide (DMF) is primarily used as a solvent and extractant, especially for salts and high-molecular-mass compounds. This application aligns with its unique combination of physical and chemical properties: low molecular mass, high dielectric constant, electron-donating ability, and complex-forming capacity.
Commercially speaking, DMF’s use as a component in synthesis is relatively insignificant. Anhydrous N,N-dimethylformamide has been utilized as a solvent in the synthesis of AN-152—a cytotoxic luteinizing hormone-releasing hormone (LH-RH) conjugate and chemotherapeutic drug—and the fluorophore C625 [4-(N,N-diphenylamino)-4′-(6-O-hemiglutarate)hexylsulfinyl stilbene]. It can also serve as a solvent medium for various organic reduction reactions.
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