Fluconazole CAS#86386-73-4
Fluconazole CAS#86386-73-4
Fluconazole, a novel triazole antifungal agent initially developed by Pfizer Pharmaceuticals in the United States, boasts broad-spectrum antifungal activity as a systemic antifungal product. It exhibits high selectivity in inhibiting fungal cytochrome P-450-dependent enzymes, while also serving as a potent and specific inhibitor of fungal alcohol synthesis.
Fluconazole Chemical Parameters
Melting point | 138-140°C |
Boiling point | 579.8±60.0 °C(Predicted) |
density | 1.05 |
Fp | 9℃ |
storage temp. | 2-8°C |
solubility | DMSO: 5 mg/mL |
form | solid |
pka | pKa 1.76±0.1(H2O t=24 I=0.1(NaCl)) (Uncertain) |
color | White to Off-White |
Water Solubility | 1g/L(temperature not stated) |
Merck | 144122 |
BCS Class | 1,3 |
InChI | InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2 |
InChIKey | RFHAOTPXVQNOHP-UHFFFAOYSA-N |
SMILES | C1(C=CC(F)=CC=1F)C(O)(CN1N=CN=C1)CN1N=CN=C1 |
CAS DataBase Reference | 86386-73-4(CAS DataBase Reference) |
Safety Information | |
Hazard Codes | Xn,Xi,T,F |
Risk Statements | 22-36/37/38-20/21/22-39/23/24/25-23/24/25-11 |
Safety Statements | 26-36-36/37/39-24/25-45-36/37-16-7 |
RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
WGK Germany | 3 |
RTECS | XZ4810000 |
HS Code | 29336990 |
Hazardous Substances Data | 86386-73-4(Hazardous Substances Data) |
Fluconazole CAS#86386-73-4 Application
Fluconazole, a broad-spectrum triazole antifungal agent, shares a similar antibacterial spectrum with ketoconazole. Characterized by long-acting properties, potent antifungal activity, and excellent oral absorption, it is highly effective against deep-seated fungal infections. Primarily indicated for the treatment of candidiasis and cryptococcosis, it also demonstrates efficacy in managing oropharyngeal candidiasis in cancer patients.
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