Doxycycline hydrochloride CAS#10592-13-9
Hydrochloride doxycycline is a light blue or yellow crystalline powder characterized by no odor, a bitter taste and hygroscopicity. It dissolves readily in water and methanol, while showing slight solubility in ethanol and acetone.This medication boasts a broad antibacterial spectrum, exerting inhibitory effects on both Gram-positive cocci and Gram-negative bacilli. Its antibacterial potency is approximately 10 times higher than that of tetracycline, and it remains effective against bacteria resistant to tetracycline.Clinically, it is primarily indicated for the treatment of respiratory tract infections, chronic bronchitis, pneumonia and urinary tract infections. Additionally, it can be employed in managing conditions such as typhus, mycoplasma pneumonia and macular eruptions.
Doxycycline hydrochloride Chemical Parameters
Melting point | 195-201℃ |
Fp | 87℃ |
storage temp. | Inert atmosphere,2-8°C |
solubility | H2O: 50 mg/mL, clear, yellow-green |
form | powder |
color | yellow |
biological source | synthetic |
Water Solubility | Soluble in water. |
BCS Class | 1 |
InChIKey | RUYHIJHUVHIMIR-PGTYNCOMNA-N |
SMILES | O[C@@]12C(C(C(=O)N)=C(O)[C@@H](N(C)C)[C@]1([H])[C@H]([C@]1([H])[C@H](C3C=CC=C(O)C=3C(=O)C1=C2O)C)O)=O.Cl |&1:1,9,13,15,16,18,r| |
CAS DataBase Reference | 10592-13-9(CAS DataBase Reference) |
Safety Information | |
Hazard Codes | Xn,Xi |
Risk Statements | 22-36/37/38 |
Safety Statements | 26-36/37 |
RIDADR | NA 1993 / PGIII |
WGK Germany | 3 |
F | 8 |
HS Code | 29413000 |
Doxycycline hydrochloride CAS#10592-13-9 Application
Its antibacterial spectrum is largely consistent with that of tetracycline and oxytetracycline, while its antibacterial activity—both in vitro and in vivo—is more potent than tetracycline. Microorganisms exhibit significant cross-resistance between this agent and counterparts like tetracycline and oxytetracycline.The medication is well absorbed via oral administration. Clinically, it is mainly used for treating upper respiratory tract infections, tonsillitis, biliary tract infections, lymphadenitis, cellulitis, and chronic bronchitis in elderly patients. These conditions are caused by sensitive Gram-positive and Gram-negative bacteria, as noted in Chemicalbook.Additionally, it is indicated for typhus, rickettsiosis, and mycoplasma pneumonia. It can also be employed in the treatment of cholera, as well as the prevention of malignant malaria and leptospirosis.
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