Trifluoromethanesulfonic acid
CAS Number: 1493-13-6
Chemical Formula: CHF3O3S
Synonyms:
Fluorad FC-24
TRIFLUOROMETHANESULPHONIC ACID
Appearance: Colorless liquid
HS Code: 29049020
MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)
Products Description of Trifluoromethanesulfonic acid CAS#1493-13-6
Trifluoromethanesulfonic acid, commonly known by aliases like triflic acid, TFMS, TFSA, HOTf, or TfOH, is a sulfonic acid with the chemical formula CF₃SO₃H. It is widely recognized as one of the strongest acids and belongs to the category of so-called "superacids".
It has broad applications in manufacturing pharmaceuticals, agricultural chemicals, and polymers, with its anhydrous form being widely used in fine chemical synthesis. Its key properties—non-oxidizing nature, high thermal stability, and resistance to both oxidation and reduction—make it one of the more useful compounds in the superacid class. In the pharmaceutical industry specifically, it is used to produce various drug types, including nucleosides, antibiotics, steroids, proteins, and glycosides. Additionally, triflic anhydride (a related compound) reacts easily with water and has an unfavorable toxicity profile.
Parameters
Melting point | -40 °C |
Boiling point | 162 °C (lit.) |
density | 1.696 g/mL at 25 °C (lit.) |
vapor density | |
vapor pressure | 8 mm Hg ( 25 °C) |
refractive index | n20/D 1.327(lit.) |
RTECS | PB2771000 |
Fp | None |
storage temp. | Store below +30°C. |
solubility | Miscible in H<sub>2</sub>O |
pka | -14(at 25℃) |
form | Fuming Liquid |
color | slightly brown |
Specific Gravity | 1.696 |
PH | <1 (H2O) |
Water Solubility | SOLUBLE |
Sensitive | Hygroscopic |
Merck | 14,9676 |
BRN | 1812100 |
Stability: | Stable. Incompatible with acids, alkalis, metals. |
InChIKey | ITMCEJHCFYSIIV-UHFFFAOYSA-N |
LogP | 0.3 at 25℃ |
CAS DataBase Reference | 1493-13-6(CAS DataBase Reference) |
NIST Chemistry Reference | CF3SO3H(1493-13-6) |
EPA Substance Registry System | Methanesulfonic acid, trifluoro- (1493-13-6) |
Safety Information
Hazard Codes | C |
Risk Statements | 21/22-35-10 |
Safety Statements | 26-36/37/39-45 |
RIDADR | UN 3265 8/PG 2 |
WGK Germany | 2 |
F | 3-10 |
Hazard Note | Corrosive/Hygroscopic |
TSCA | Yes |
HazardClass | 8 |
PackingGroup | II |
HS Code | 29049020 |
Toxicity | LD50 orally in Rabbit: 1605 mg/kg LD50 dermal Rat > 2000 mg/kg |
Product Application of Trifluoromethanesulfonic acid CAS#1493-13-6
Trifluoromethanesulfonic acid serves multiple functions: it acts as a catalyst in Friedel-Crafts-type reactions such as acylation, alkylation, and polymerization; it works as a solvent for electron spin resonance (ESR); and it functions as a nonaqueous strong acid titrant. It is also used together with trifluoroacetic acid in solid-phase peptide synthesis. Additionally, it is recognized as one of the strongest monoprotic acids available.
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