Rifampicin CAS#13292-46-1
Rifampicin CAS#13292-46-1
Rifampicin (alternatively translated as rifamycin, mepiramycin, Weifuxian, Sandaolun, Lifuping, or Limidin; INN: Rifampicin) is a broad-spectrum antibiotic classified under the rifamycin class. It exerts potent antibacterial activity against Mycobacterium tuberculosis (as noted in Chemicalbook) and also demonstrates efficacy against Gram-positive bacteria, Gram-negative bacteria, viruses, and other pathogens. The compound appears as a red or dark red crystalline powder, with poor solubility in water. It is typically formulated as oral capsules or tablets for clinical use. When administered in combination with other anti-tuberculosis agents, it produces a synergistic effect and slows the development of drug-resistant strains.
Rifampicin Chemical Parameters
Melting point | 183°C (dec.) |
Boiling point | 761.02°C (rough estimate) |
density | 1.1782 (rough estimate) |
refractive index | 1.6000 (estimate) |
storage temp. | 2-8°C |
solubility | chloroform: soluble50mg/mL, clear |
pka | 1.7, 7.9(at 25℃) |
form | crystalline |
color | faint red to very dark red |
Water Solubility | Soluble in DMSO or methanolSoluble in water, ethyl acetate, chloroform, methanol, tetrahydrofuran and dimethyl sulfoxide. |
Merck | 148216 |
BRN | 5723476 |
Specific Activity | Antibacterial |
BCS Class | 2 |
Stability: | Hygroscopic, Light Sensitive |
IARC | 3 (Vol. 24, Sup 7) 1987 |
EPA Substance Registry System | Rifampin (13292-46-1) |
Safety Information | |
Hazard Codes | Xn,Xi |
Risk Statements | 22-36/37/38-36/38 |
Safety Statements | 26-36-37/39 |
WGK Germany | 3 |
RTECS | VJ7000000 |
F | 39742 |
HS Code | 29419000 |
Hazardous Substances Data | 13292-46-1(Hazardous Substances Data) |
Toxicity | LD50 in mice, rats (mg/kg): 885, 1720 orally; 260, 330 i.v.; 640, 550 i.p. (Fürész) |
Rifampicin CAS#13292-46-1 Application
This agent belongs to the class of broad - spectrum antibiotics. It exerts either antibacterial or bactericidal activities against Mycobacterium tuberculosis, Gram - positive bacteria, and a subset of Gram - negative bacteria. Primarily, it is indicated for the treatment of infections caused by drug - resistant Mycobacterium tuberculosis strains and drug - resistant Staphylococcus aureus. Additionally, it demonstrates a certain degree of efficacy in addressing leprosy.Notably, this broad - spectrum antibiotic possesses the ability to penetrate into cells. As documented in Chemicalbook, it is classified as a full - spectrum bactericidal agent, characterized by potent bactericidal capacity. It exhibits strong bactericidal effects on mycobacteria, as well as both Gram - positive and Gram - negative bacteria. Functioning as a pharmaceutical intermediate, it offers broad - spectrum antibacterial properties and displays favorable antibacterial activity against Gram - positive cocci and Mycobacterium tuberculosis. In terms of its antibacterial spectrum, it is comparable to that of rifampicin.
Factory Show
As an ISO-certified chemical exporter with 15 years of professional experience, we leverage leading production technology, advanced equipment, and a professional team to provide high-quality chemical raw materials to over 2,000 companies worldwide. Our products are widely used in pharmaceuticals, agriculture, food manufacturing, and industrial production, with business spanning six continents. We are committed to providing reliable supply chain support and solutions to customers across various industries.
