Hydroxypropyl methyl cellulose CAS# 9004-65-3
Hydroxypropyl methyl cellulose (HPMC) is the propylene glycol ether of methyl cellulose. Its hydroxypropyl and methyl groups bond to anhydrous glucose rings via ether linkages.It appears as a white or off-white cellulose powder or granular material—some variants may also be grayish fibrous powder or particles. Different product grades have varying ratios of methoxy to hydroxypropyl content.HPMC dissolves in water and certain organic solvents but is insoluble in ethanol. Its aqueous solution has surface activity, forming a film when dried. When heated and then cooled, it undergoes a reversible transformation from sol to gel.
Hydroxypropyl methyl cellulose Chemical Parameters
Melting point | 225-230 °C |
density | 1.39 |
storage temp. | room temp |
solubility | H2O: 50 mg/mL, clear to very faintly turbid, faintly yellow |
form | powder |
color | White to cream |
Odor | Odorless |
PH | 5.0-8.0 |
biological source | plant |
Water Solubility | SOLUBLE |
Merck | 14,4842 |
Stability: | Stable. Solid is combustible, incompatible with strong oxidizing agents. |
EPA Substance Registry System | 2-Hydroxypropyl methyl cellulose (9004-65-3) |
Safety Information
Safety Statements | 24/25 |
WGK Germany | 1 |
RTECS | NF9125000 |
F | 3-10 |
TSCA | Yes |
HS Code | 39129000 |
Hydroxypropyl methyl cellulose CAS# 9004-65-3 Application
Hydroxypropyl Methyl Cellulose (HPMC) is a water-soluble polymer made from cellulose. It’s commonly used as a thickener, binder, film former, and water retention agent. It also works as a suspension aid, surfactant, lubricant, protective colloid, and emulsifier. Plus, its solutions form a gel when heated.
HPMC has many great properties, with uses across different industries:
（1）Food industry: stabilizes emulsions and foams, replaces fat, acts as a non-caloric bulking agent, and serves as a binder.
（2）Pharmaceutical industry: functions as a dispersing and thickening agent, coats tablet films, and is used in drug formulations.
（3）Cosmetics industry: added to hair shampoos, eye makeup products, and skin care preparations.
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