Methylprednisolone
Methylprednisolone CAS#83-43-2
Methylprednisolone (CAS Number: 83-43-2) is a synthetic glucocorticoid medication with moderate potency. Endowed with potent anti-inflammatory, immunomodulatory and anti-allergic effects, it occupies a crucial role in clinical practice.Classified as a glucocorticoid agent, methylprednisolone is indicated for the emergency treatment of life-threatening conditions. It is also applicable in managing endocrine disorders, rheumatic diseases, collagenopathies, dermatological conditions, allergic reactions, ophthalmic diseases, gastrointestinal disorders, hematological diseases, leukemia, shock, cerebral edema, multiple neuritis and myelitis. Additionally, it can be used to prevent chemotherapy-induced nausea and vomiting in cancer patients.
Methylprednisolone Chemical Parameters
Melting point | 228-237°C (dec.) |
alpha | D20 +83° (dioxane) |
Boiling point | 423.47°C (rough estimate) |
density | 1.0868 (rough estimate) |
refractive index | 82 ° (C=1, Dioxane) |
storage temp. | 0-6°C |
solubility | chloroform/methanol (9:1): 50 mg/mL, clear, faintly yellow |
pka | 12.46±0.70(Predicted) |
form | Solid |
color | White to Off-White |
Water Solubility | 0.12g/L(25 ºC) |
Merck | 146111 |
BRN | 2340300 |
BCS Class | 2 or 4? |
InChIKey | VHRSUDSXCMQTMA-PJHHCJLFSA-N |
CAS DataBase Reference | 83-43-2(CAS DataBase Reference) |
NIST Chemistry Reference | 1,4-Pregnadiene-3,20-dione, 11beta,17alpha,21-trihydroxy-6alpha-methyl-(83-43-2) |
EPA Substance Registry System | Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-6-methyl-, (6.alpha.,11.beta.)- (83-43-2) |
Safety Information | |
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 22-36-26 |
WGK Germany | 2 |
RTECS | TU4146000 |
F | 39744 |
HS Code | 2937290000 |
Hazardous Substances Data | 83-43-2(Hazardous Substances Data) |
Methylprednisolone CAS#83-43-2 Application
Methylprednisolone (CAS Registry Number: 83-43-2) is a medium-potency glucocorticoid with anti-inflammatory, immunosuppressive and anti-allergic properties. Clinically, it is employed for treating acute flares of rheumatic and immune disorders (e.g., rheumatoid arthritis), acute exacerbations of respiratory diseases like bronchial asthma, as well as digestive system conditions such as ulcerative colitis.
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