Ceftriaxone sodium CAS#104376-79-6
CAS Number: 104376-79-6
Chemical Formula: C18H21N8NaO8S3
Synonyms:
Ceftriaxone SodiuM Trihydrate
Ceftriaxone sodiuM sesquaterhydrate
(6R,7R)-7-[[(2Z)-2-(2-AMino-4-thiazolyl)-2-(MethoxyiMino)acetyl]aMino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-Methyl-Chemicalbook5,6-dioxo-1,2,4-triazin-3-yl)thio]Methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicAcidSodiuMSaltHydrate
Appearance: White solid
HS Code:29349990
MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)
Ceftriaxone sodium CAS#104376-79-6
Ceftriaxone, a third-generation broad-spectrum cephalosporin antibiotic, inhibits bacterial cell wall synthesis by disrupting peptidoglycan layer formation. In both in vitro and in vivo studies, it enhances excitatory amino acid transporter-2 pump expression in the central nervous system and mitigates glutamatergic toxicity.
Ceftriaxone sodium Chemical Parameters
Melting point | 236 °C |
alpha | D25 -165° (c = 1 in water) (calc for water-free substance) |
refractive index | -160 ° (C=1, H2O) |
storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
solubility | H2O: soluble50mg/mL |
pka | ~3 (COOH), 3.2 (NH3+), 4.1 (enolic OH) |
form | powder or crystals |
color | White to Off-White |
Water Solubility | Freely soluble in water |
InChIKey | FDRNWTJTHBSPMW-BBJOQENWSA-L |
Safety Information | |
Hazard Codes | Xn |
Risk Statements | 36/37/38-42/43 |
Safety Statements | 26-36-45-37-24-22 |
WGK Germany | 1 |
RTECS | XI0368800 |
HS Code | 29349990 |
Toxicity | LD50 in male, female, mice, rats (mg/kg): 3000, 2800, 2175, 2175 i.v.; >10000 all species orally; >5000 all species s.c. (Teelman) |
MSDS Information | |
Provider | Language |
SigmaAldrich | English |
Ceftriaxone sodium Usage And Synthesis | |
Description | Ceftriaxone is a third-generation, broad-spectrum cephalosporin antibiotic that disrupts the synthesis of the peptidoglycan layer of bacterial cell walls. It has been shown to increase excitatory amino acid transporter-2 pump expression in the central nervous system and to reduce glutamatergic toxicity in both in vitro and in vivo models. |
Chemical Properties | White Crystalline Solid |
Uses | antipsychotic |
Uses | A potentially useful antibacterial agent for proteomics research. |
Uses | An antibacterial, a third-generation cephalosporin. |
Definition | ChEBI: Ceftriaxone disodium salt hemiheptahydrate is a cephalosporin. |
Brand name | Rocephin (Roche). |
Biological Activity | β -lactam antibiotic. Displays neuroprotective activity in vivo via upregulation and increased activity of the EAAT2 glutamate transporter. |
Ceftriaxone sodium CAS#104376-79-6 Application
Ceftriaxone sodium (CAS#104376-79-6) is a third-generation cephalosporin antibiotic that eradicates microorganisms by blocking bacterial cell wall synthesis. It features a broad antibacterial spectrum and high stability, making it suitable for treating susceptible bacterial infections in multiple body systems, including the respiratory, urinary, abdominal, and pelvic regions.
Factory Show
As an ISO-certified chemical exporter with 15 years of professional experience, we leverage leading production technology, advanced equipment, and a professional team to provide high-quality chemical raw materials to over 2,000 companies worldwide. Our products are widely used in pharmaceuticals, agriculture, food manufacturing, and industrial production, with business spanning six continents. We are committed to providing reliable supply chain support and solutions to customers across various industries.
