Carbamazepine CAS#298-46-4
Carbamazepine appears as a white or slightly off-white crystalline powder, classified under the dibenzazepine family of antiepileptic medications. Its antiepileptic properties bear resemblance to those of phenytoin sodium, with particular efficacy in managing psychomotor seizures. Additionally, it demonstrates effectiveness against grand mal seizures, focal seizures, and mixed seizure types.When it comes to treating peripheral neuropathy, carbamazepine outperforms phenytoin sodium, making it a viable option for addressing trigeminal neuralgia and glossopharyngeal neuralgia. Beyond these applications, it can also be utilized in the treatment of cardiac arrhythmias and diabetes insipidus.
Carbamazepine Chemical Parameters
Melting point | 191-192 °C (lit.) |
Boiling point | 378.73°C (rough estimate) |
density | 1.1099 (rough estimate) |
refractive index | 1.5906 (estimate) |
Fp | 9℃ |
storage temp. | 2-8°C |
solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble29mg/mL |
form | Crystals |
pka | 13.94±0.20(Predicted) |
color | Almost white |
Water Solubility | pract. insoluble |
Merck | 141781 |
BCS Class | 2 |
LogP | 2.45 |
CAS DataBase Reference | 298-46-4(CAS DataBase Reference) |
NIST Chemistry Reference | Carbamazepine(298-46-4) |
EPA Substance Registry System | 5H-Dibenz[b,f]azepine-5-carboxamide (298-46-4) |
Safety Information | |
Hazard Codes | Xn,T,F |
Risk Statements | 42/43-22-20/21/22-39/23/24/25-23/24/25-11 |
Safety Statements | 37-24-22-36/37/39-36-45-36/37-16 |
RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
WGK Germany | 2 |
RTECS | HN8225000 |
HS Code | 29339900 |
Hazardous Substances Data | 298-46-4(Hazardous Substances Data) |
Toxicity | LD50 orally in mice, rats: 3750, 4025 mg/kg (Stenger, Roulet) |
Carbamazepine CAS#298-46-4 Application
Carbazine is categorized as a dibenzazepine-type antiepileptic agent, exhibiting anticonvulsant activities comparable to those of phenytoin sodium. It exerts the greatest therapeutic effect on psychomotor seizures while also proving effective against generalized tonic-clonic seizures (grand mal), focal seizures (localized seizures), and mixed seizure disorders.In terms of peripheral neuropathy management, as noted in Chemicalbook, this medication surpasses phenytoin sodium in efficacy. It is indicated for the treatment of trigeminal neuralgia and glossopharyngeal neuralgia, and may also be employed in addressing cardiac arrhythmias and diabetes insipidus. The oral median lethal dose (LD50) is 3750 mg/kg in mice and 4025 mg/kg in rats.Functionally, it acts as an anticonvulsant, utilized in the management of generalized tonic-clonic seizures and psychomotor epilepsy, as well as in the treatment of trigeminal neuralgia. Additionally, it serves as a ligand targeting the benzodiazepine regulatory sites of GABAA receptors and functions as a sodium ion channel inhibitor.
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