Dexamethasone CAS#50-02-2
Dexamethasone is a widely utilized clinical medication, frequently administered in combination with other drugs. Possessing anti-inflammatory, detoxifying and anti-allergic properties, it lacks direct therapeutic effects on the underlying disease itself—its primary function is to alleviate or suppress inflammatory manifestations. For this reason, caution is imperative in clinical application: it is generally not used as a monotherapy, and must be combined with other medications to achieve optimal efficacy.
Dexamethasone Chemical Parameters
Melting point | 262-264 °C (lit.) |
alpha | 75 º (c=1, dioxane) |
Boiling point | 568.2±50.0 °C(Predicted) |
density | 1.1283 (estimate) |
refractive index | 76 ° (C=1, Dioxane) |
Fp | 9℃ |
storage temp. | 2-8°C |
solubility | ethanol: 1 mg/mL |
form | powder |
pka | 12.13±0.70(Predicted) |
color | off-white |
biological source | synthetic (organic) |
Water Solubility | 10 mg/100 mL (25 ºC) |
Sensitive | Light Sensitive |
Merck | 142943 |
BRN | 2066651 |
BCS Class | 1 (CLogP), 3 (LogP) |
Stability: | Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, acid anhydrides, acid chlorides. May be light sensitive. |
InChIKey | UREBDLICKHMUKA-CXSFZGCWSA-N |
CAS DataBase Reference | 50-02-2(CAS DataBase Reference) |
NIST Chemistry Reference | Prednisolone, 9alpha-fluoro-16alpha-methyl-(50-02-2) |
EPA Substance Registry System | Dexamethasone (50-02-2) |
Safety Information | |
Hazard Codes | Xi,Xn,T,F |
Risk Statements | 43-40-36/37/38-20/21/22-42/43-39/23/24/25-23/24/25-11 |
Safety Statements | 36/37-45-36-26-22-16 |
RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
WGK Germany | 2 |
RTECS | TU3980000 |
TSCA | Yes |
HS Code | 29372210 |
Hazardous Substances Data | 50-02-2(Hazardous Substances Data) |
Toxicity | LD50 oral in rat: > 3gm/kg |
Dexamethasone CAS#50-02-2 Application
Dexamethasone (specifically dexamethasone sodium phosphate EP impurity A) is a glucocorticoid with anti-inflammatory activity. This agent modulates the survival, proliferation and differentiation of T cells while suppressing the induction of nitric oxide synthase. Primarily indicated for anti-inflammatory and anti-allergic uses, it is applicable in the management of rheumatoid arthritis and other collagen-related disorders.
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