Kojic Acid#501-30-4
Kojic acid is a natural product of Aspergillus oryzae and other fungi. As a tyrosinase inhibitor, its core function is to chelate copper ions in the enzyme, thereby blocking melanin production, which gives it skin-whitening effects.
Kojic acid Chemical Properties
Melting point | 152-155 °C (lit.) |
Boiling point | 179.65°C (rough estimate) |
density | 1.1712 (rough estimate) |
refractive index | 1.4434 (estimate) |
storage temp. | Store below +30°C. |
solubilit | DMSO (Slightly), Methanol (Slightly, Sonicated) |
form | Crystalline Powder |
pka | 7.9(at 25℃) |
color | White to beige-brown |
Water Solubility | SOLUBLE |
λmax | 269nm(CHCl3)(lit.) |
Merck | 14,5317 |
BRN | 120895 |
Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
LogP | -0.640 |
CAS DataBase Reference | 501-30-4(CAS DataBase Reference) |
NIST Chemistry Reference | 5-Hydroxy-2-(hydroxymethyl)-4h-pyran-4-one(501-30-4) |
IARC | 3 (Vol. 79) 2001 |
EPA Substance Registry System | Kojic acid (501-30-4) |
Safety Information
Hazard Codes | Xn |
Risk Statements | 40-68 |
Safety Statements | 22-24/25-36/37-36 |
WGK Germany | 3 |
RTECS | UQ0875000 |
HS Code | 29329995 |
Hazardous Substances Data | 501-30-4(Hazardous Substances Data) |
Kojic acid#501-30-4 Application
Kojic acid, as a skin-whitening ingredient, primarily relies on its antioxidant activity. It's also a tyrosinase inhibitor, though not as potent as licorice extract.
In practice, kojic acid is often combined with allantoin and other suitable ingredients in sunscreen products to reduce UV-induced erythema and promote faster wound healing. However, it's important to note that kojic acid has potential side effects, including potential skin sensitivity and irritation.
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